Transcriptional Regulation of Chemical Diversity in Aspergillus fumigatus by LaeA
نویسندگان
چکیده
منابع مشابه
Transcriptional Regulation of Chemical Diversity in Aspergillus fumigatus by LaeA
Secondary metabolites, including toxins and melanins, have been implicated as virulence attributes in invasive aspergillosis. Although not definitively proved, this supposition is supported by the decreased virulence of an Aspergillus fumigatus strain, DeltalaeA, that is crippled in the production of numerous secondary metabolites. However, loss of a single LaeA-regulated toxin, gliotoxin, did ...
متن کاملRole of laeA in the Regulation of alb1, gliP, Conidial Morphology, and Virulence in Aspergillus fumigatus.
The alb1 (pksP) gene has been reported as a virulence factor controlling the pigmentation and morphology of conidia in Aspergillus fumigatus. A recent report suggested that laeA regulates alb1 expression and conidial morphology but not pigmentation in the A. fumigatus strain AF293. laeA has also been reported to regulate the synthesis of secondary metabolites, such as gliotoxin. We compared the...
متن کاملThe Aspergillus fumigatus transcriptional regulator
for defense against reactive oxygen intermediates but is dispensable for pathogenicity in an 2 intranasal mouse infection model 3 4 Abstract 1 Macrophages and neutrophils kill the airborne fungal pathogen Aspergillus fumigatus. The 2 dependency of this killing process on reactive oxygen intermediates (ROI) was strongly 3 suggested. Therefore, we investigated the enzymatic ROI detoxifying system...
متن کاملRegulation of Development in Aspergillus nidulans and Aspergillus fumigatus
Members of the genus Aspergillus are the most common fungi and all reproduce asexually by forming long chains of conidiospores (or conidia). The impact of various Aspergillus species on humans ranges from beneficial to harmful. For example, several species including Aspergillus oryzae and Aspergillus niger are used in industry for enzyme production and food processing. In contrast, Aspergillus ...
متن کاملSreA-mediated iron regulation in Aspergillus fumigatus
Aspergillus fumigatus, the most common airborne fungal pathogen of humans, employs two high-affinity iron uptake systems: iron uptake mediated by the extracellular siderophore triacetylfusarinine C and reductive iron assimilation. Furthermore, A. fumigatus utilizes two intracellular siderophores, ferricrocin and hydroxyferricrocin, to store iron. Siderophore biosynthesis, which is essential for...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS Pathogens
سال: 2007
ISSN: 1553-7374
DOI: 10.1371/journal.ppat.0030050